Differences between: PAM vs BLOSUM

biology
differences
Published

October 9, 2024

PAM and BLOSUM are both substitution matrix for amino acid. This is a high level overview of their differences.

You can download the image from here.

from IPython.display import display, HTML
import warnings

warnings.filterwarnings("ignore")
display(HTML('<iframe frameborder="0" style="width:100%;height:800px;" src="https://viewer.diagrams.net/?tags=%7B%7D&lightbox=1&highlight=0000ff&edit=_blank&layers=1&nav=1&title=blosumVSpam.drawio#Uhttps%3A%2F%2Fdrive.google.com%2Fuc%3Fid%3D1fjtAgobn9ve0DzsDLo7zAyWCGsUtPXRA%26export%3Ddownload"></iframe>'));

Reference & credit:

  1. Dr. Rob Edwards: BLAST playlist
  2. Wikipedia: Tyrosine
  3. Wikipedia: Phenylalanin
  4. Human Genome Variation Society: Codon & amino acids